All authors specify that the frequent risk factors in the occurrence of pulmonary edema that can represent a potential trigger are represented by ischemia reperfusion syndrome, prolonged cardiac bypass time without pulmonary ventilation, generalized inflammatory response (Il-6, IL-8, IL-17) [10,22,23,24], documented sepsis (peritonitis, pancreatitis, endocarditis) [9], anesthesia, hypothermia, surgery, medications, blood transfusions, inflammatory hyperreactivity, or maybe even an hyperimmune response [25,26]. The gene discussed is IL6; the disease is endocarditis.