Moreover, cranial radiotherapy in doses exceeding 30 Gy via hypothalamic–pituitary axis disfunction and GH deficiency promotes either the overproduction of leptin by adipose tissue and leptin resistance at hypothalamic receptors level or lipid and free fatty acid oxidation, insulin resistance, and changes in body composition, leading to an increased android–gynoid fat ratio and promoting the onset of dyslipidemia and central obesity [3,5,7,8,9,10,11]. This evidence concerns the gene LEP and metabolic syndrome.