In the frequent exacerbation group, the analysis of cytokine profiles stratified by ACT scores showed that the association of cytokine levels with asthma control assessed by the ACT score were not significant for any of the mediators: IL-17 (9.74 pg/mL, IQR 4.22–17.70 vs. 8.16 pg/mL, IQR 1.47–14.43, p = 0.36), IFN-α (0.80 pg/mL, IQR 0.34–1.54 vs. 0.56 pg/mL, IQR 0.40–1.0, p = 0.37), TNF-α (11.59 pg/mL vs. 7.75 pg/mL, p = 0.14), IL-1β (2.04 pg/mL vs. 1.16 pg/mL, p = 0.14), and notably IL-12 (140.96 pg/mL, IQR 29.14–332.72 vs. 45.67 pg/mL, IQR 27.68–257.42, p = 0.32). This evidence concerns the gene IL1B and asthma.