Nonetheless, the analysis of cytotoxic factors (Fas ligand, TNF-related apoptosis-inducing ligand, perforin, Granzyme B) and cytokine secretion showed a significant rise in the TNF-related apoptosis-inducing ligand-positive CD8+ lymphocytes and cells producing IFN-γ in NSCLC. This evidence concerns the gene TNFSF10 and non-small cell lung carcinoma.