We report a case of EGFR‐, TP53‐, and Cullin 3 (CUL3)‐mutant NSCLC in a 43‐year‐old woman with widespread metastases at diagnosis, including those in the contralateral lung, distant lymph nodes, pericardium, liver, bones, left adrenal gland, and brain. This evidence concerns the gene TP53 and non-small cell lung carcinoma.