These factors may play a role in the development and progression of heart failure, and intervening in them could be beneficial in the treatment of heart failure.Additionally, our reverse Mendelian randomization study indicated that heart failure might lead to fluctuations in the levels of four inflammatory factors (ARTN, FGF5, MMP-10, SLAM), which could potentially serve as biomarkers for predicting heart failure in the future. The gene discussed is FGF5; the disease is heart failure.