Despite the lack of an alleviative effect of IA intervention on weight loss in mice, it effectively mitigated allergic and diarrhea symptoms, as well as OVA-sIgE, HIS, and Th2-type cytokine levels in the jejunum, and enhanced the expression of tight junction proteins ZO-1 and Occludin, thereby alleviating intestinal injury induced by food allergy. This evidence concerns the gene TJP1 and food allergy.