LRRK2 and Parkinson disease: While previous studies on the proteome of urinary EVs and the CSF of LRRK2 PD patients have been performed, to the best of our knowledge this was the first study that directly characterized the proteome of dopaminergic neurons carrying an LRRK2 mutation and their EVs (Karayel et al., 2022; Hadisurya et al., 2023; Virreira Winter et al., 2021).