Studying the contribution of OXT as an endogenous hormone, along with its genetic and epigenetic contribution to a stress-related disorder like FND is highly relevant,45 eventhough genetic and epigenetic studies require large cohorts.46 Thus, in this study, we aimed to look at the peripheral levels of salivary OXT, taking into account the genotype variant at rs53576 SNP of the OXTR gene, the OXTR’s methylation rates and neuroimaging data (both structural and resting-state FC) in a well-characterized population of patients with mixed FND symptoms compared with healthy controls (HCs). Here, OXT is linked to stress-related disorder.