Systematic reviews on OXTR methylation indeed concluded that methylation would facilitate flexibility in the regulation of the oxytocin system in various environments and contexts and that a differential methylation pattern could be interpreted as a contributing factor.27,81 Thus, in FND, the biological mechanisms of OXTR and OXT interaction might not exert the same protective role as what has been found in HC8 or which has been discussed as a compensatory regulation for anxiety.79 The gene discussed is OXTR; the disease is Anxiety.