Kaleigh and colleagues suggested that the presence of bilateral renal artery stenosis was not associated with renin-angiotensin inhibitor use; in contrast, people with renal artery stenosis who received renin-angiotensin inhibitor treatment had significant benefits of blood pressure control, progression of renal disease, cardiovascular outcomes, and reduced all-cause mortality (Evans et al., 2014; Chrysochou et al., 2012). The gene discussed is REN; the disease is Renal artery stenosis.