Furthermore, it has been observed (Jiao et al., 2019) that API can inhibit Wnt/β-catenin signaling in a concentration-dependent manner, leading to the downregulation of Wnt target genes such as the myelocytomatosis viral oncogene homolog, recombinant axis inhibition protein 2 (AXIN2), and recombinant cyclin D1 (CCND1), thereby reducing tumor cell invasion as illustrated in Figure 3. Here, CCND1 is linked to neoplasm.