TRPM4 and Arrhythmia: In cardiac electrophysiology, TRPM4 channels influence membrane potential to alter excitability through participation in membrane voltage regulation of intracellular Ca2+ (Guinamard et al., 2015; Abriel et al., 2012; Guinamard et al., 2014; Mathar et al., 2014), which is closely related to arrhythmias.