Lymphangiogenic factors secreted by pre-metastatic tumors, including VEGF-A, VEGF-C and VEGF-D, are absorbed by lymphatic capillaries around the tumor and transported by the collecting lymphatic vessels to the TDLNs, where they act directly on pre-existing lymphatic vessels to induce lymphangiogenesis (Alitalo and Detmar, 2012). This evidence concerns the gene VEGFC and neoplasm.