VEGFC and cancer: In human cancer, lymphangiogenic growth factor VEGF-C expression is correlated with lymphatic metastasis and shorten survival, while tumoral expression of VEGF-C promotes lymphatic metastasis and blocking VEGFR-3 signaling could inhibit lymphatic metastasis (Chen et al., 2020; Kong et al., 2020; Paillasse et al., 2022).