CALCA and osteoporosis: Yeh CB et al. and Ito A et al. report that calcitonin can partially reverse ovariectomy-induced hypersensitivity in a rat models and alleviate lower back pain in patients with osteoporosis or neuropathic pain by the modulating receptor or channel expression in thalamus (Yeh et al., 2016; Ito and Yoshimura, 2017).