TNF and neoplasm: NR4A1 has been confirmed to have anti-tumor effects in various tumors (Beard, Tenga & Chen, 2015; Wenzl et al., 2015; Wu et al., 2017), and research has shown that NR4A1 significantly enhances TNF α-induced GC cell apoptosis by inhibiting mitochondrial autophagy (Yan et al., 2018).