IL-35 is a member of the IL-12 family with anti-inflammatory process, while IL-4 and IL-13 are two structurally and functionally related cytokines to T help 2 cells which can modulate the immune response and tumor microenvironment under normal physiological conditions and cancer (Xue, Yan & Kan, 2019; Suzuki et al., 2015). This evidence concerns the gene IL4 and neoplasm.