PVALB and Creutzfeldt Jacob disease: Conversely, in addition to the loss of parvalbumin-positive GABAergic neurons in CJD patients and experimental animals (Belichenko et al., 1999; Guentchev et al., 1997; Guentchev et al., 1999), recent single-cell transcriptome analysis indicates the vulnerability of inhibitory neurons in the hippocampus to prion infection (Slota et al., 2022).