Interestingly, our data show that in early time point (6 h) after CLP induced-sepsis, no changes were found in myocardial Gpx4 protein level, cardiac iron and MDA, suggesting that the myocardial ferroptosis signaling might not be the major drivers for the pathological changes in the early phase of sepsis-induced cardiomyopathy in mice. This evidence concerns the gene GPX4 and Sepsis.