Additional frequent genomic alterations in meningioma include mutations in TNF receptor associated factor 7 (TRAF7), KLF transcription factor 4 (KLF4), and phosphatidylInositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) (9, 10). The gene discussed is PIK3CA; the disease is meningioma.