NF2 and neoplasm: Loss of NF2 leads to disruption of Merlin, a key tumor suppressor that targets multiple signaling pathways such as mTORC1 (cell growth and metabolism in response to environmental factors), Ras/Rac/PAK (cellular proliferation, differentiation, and transformation), and CRL4-DCAF (DNA damage response and mitotic exit) (60, 61).