Chromosome 1p loss leads to reduced expression of several genes including patched 2 (PTCH2) (21), AT-rich interaction domain 1A (ARID1A) (22, 23), alkaline phosphatase, biomineralization associated (ALPL) (24, 25), and cyclin dependent kinase inhibitor 2C (CDKN2C) (26).Type A and B meningiomas tend to follow a more benign course and type C are enriched for recurrent meningiomas. The gene discussed is ALPL; the disease is meningioma.