Transgenic mice expressing mutant forms of human Tau protein, such as P301L or P301S mutations, develop Tau pathology, including Tau hyperphosphorylation, aggregation, and neurofibrillary tangle formation (Yoshiyama et al., 2007; Lewis et al., 2000), similar to what is observed in human Tauopathies (Kovacs, 2017). The gene discussed is MAPT; the disease is tauopathy.