We recently reported that SUMO2 conjugation is reduced in the hippocampus of PS19 mice, which express human Tau with the P301S mutation (Yoshiyama et al., 2007), at 8 months of age, when Tau pathology and the associated cognitive impairments and neurodegeneration are already present (Orsini et al., 2022). The gene discussed is MAPT; the disease is Cognitive impairment.