APS patients with β2-GPI-dependent LAC are reported to have higher levels of the unfolded form of VWF (7, 12, 13) We have previously shown that anti-β2-GPI antibodies do not increase the expression of active VWF, but inhibit the antithrombotic capacity of β2-GPI. This evidence concerns the gene VWF and autoimmune polyendocrinopathy.