Adjusting for age and sex strengthened the association between high unfolded VWF levels and APS (OR: 8.51; CI:3.26 - 22.2; p<0.001), thrombosis (OR:5.87; CI:2.07 - 16.7, p=0.001) and AID (OR:3.71; CI:1.40 – 9.87; p=0.009; Figure 3). The gene discussed is AICDA; the disease is autoimmune polyendocrinopathy.