In HCC with high expression of caspase-8, cFLIP not only blocks caspase-8-mediated apoptosis but also modulates NF-κB pathways through the caspase-8-FADD-cFLIP-RIPK1 complex, promoting the survival and drug resistance of HCC (101, 102). Here, RIPK1 is linked to hepatocellular carcinoma.