Conversely, in tumor cells lacking caspase-10, TRAF2, or ATR, the mode of cell death shifts to a more effective autocrine/paracrine mode, initiated by another complex, the FLIPosome, which results in the processing of cFLIPL and the production of TNF-α, promoting p53-independent apoptosis (186). The gene discussed is CFLAR; the disease is neoplasm.