Furthermore, a univariate Cox regression analysis of the pan-cancer cohorts revealed that SNRPE expression was negatively correlated with prognosis across multiple cancer types, including Adrenocortical Carcinoma (ACC), Head and Neck squamous cell carcinoma (HNSC), Kidney Chromophobe (KICH), Kidney renal clear cell carcinoma (KIRC), liver hepatocellular carcinoma (LIHC), Brain Lower Grade Glioma (LGG), Lung adenocarcinoma (LUAD), and Pheochromocytoma and Paraganglioma (PCPG) (Supplementary Figure S3A). The gene discussed is SNRPE; the disease is head and neck squamous cell carcinoma.