While TSLP is a key regulator in mediating Th2 allergic inflammation, excessive TSLP activity in the airway epithelium can trigger and perpetuate atopic asthma, a common disorder characterized by tissue obstruction and remodeling in the airway, bronchial smooth muscle cell hyperreactivity to allergens and chronic bronchial inflammation (16, 17). Here, TSLP is linked to atopic asthma.