The capability of induction of typical asthma phenotypes, including airway hyperresponsiveness, mucus production, eosinophilic infiltration and elevated IgE level, by the intranasal administration of human TSLP along with OVA corroborated the functional integrity of human TSLP-TSLPR signal cascade in the transgenic mice. This evidence concerns the gene TSLP and airway hyperresponsiveness.