The random forest model identified key DEGs crucial for classifying SAH and dementia, with METRNL, KHDRBS1, SLC6A1, TNFAIP8L1, and PAPOLA being the primary discriminators for SAH, and METRNL, NT5DC1, ZNF627, TUBG2, and TNFAIP8L1 crucial for dementia classification (Figures 2G, H). This evidence concerns the gene METRNL and dementia.