Next, we performed CD8 staining in tumor sections from patients who underwent immunochemotherapy to classify them into four groups based on CD8+ T-cell infiltration: response with CD8+ T-cell infiltration (R-infiltrated), no response with CD8+ T-cell infiltration (NR-infiltrated), no response with CD8+ T-cell infiltration surrounding the tumor (NR-excluded), and no response with minimal CD8+ T-cell staining (NR-desert) according to a previous study (36) (Figure 7A). Here, CD8A is linked to neoplasm.