NFKB1 and neoplasm: In innate immunity, METTL3 influences macrophage polarization, promoting the shift of bone marrow-derived macrophages from M1 to M2 polarization via the NF-κB and STAT3 pathways, thereby enhancing tumor infiltration and leading to reduced therapeutic efficacy of PD-1 monoclonal antibodies, accelerating tumor progression and distant metastasis (40).