SHISA2 and breast cancer: These genes play important roles in a variety of cancers, such as EME1 interacts with Mus81 to form a structure-specific nucleic acid endonuclease that maintains genome stability in mammalian cells (27) and is involved in regulating the development of cancers such as gastric cancer and breast cancer (28, 29), Wnt family member 4 (WNT4) is involved in regulating the progression of cancers such as gastric cancer and germline tumors (30, 31), SHISA2 is highly expressed in high-grade prostate (32).