Grounded in the candidate genes connected to HF development in sheep (Supplementary Table S15), 11 core genes (|MM| ≥ 0.75), namely, DBI, FZD3, KRT17, ZDHHC21, TGM3, DSG4, TMEM79, KRT84, HOXC13, LOC101116039, and MSX2 were identified in the red, green, and turquoise modules as being involved in the control of HF growth and development in sheep. The gene discussed is KRT17; the disease is hydrops fetalis.