KEGG analysis revealed that A pattern transcripts were primarily enriched in pathways related to systemic lupus erythematosus, alcoholism, neutrophil extracellular trap formation, estrogen signaling, necroptosis, and metabolic pathways (Figure 6D; Supplementary Figures S2A,B), whereas T pattern transcripts were mainly enriched in pathways associated with salivary secretion, oxytocin signaling, Apelin signaling, circadian entrainment, cGMP-PKG signaling, and Rap1 signaling (Figure 6D; Supplementary Figures S2C,D). This evidence concerns the gene APLN and alcohol dependence.