Grounded in the candidate genes connected to HF development in sheep (Supplementary Table S15), 11 core genes (|MM| ≥ 0.75), namely, DBI, FZD3, KRT17, ZDHHC21, TGM3, DSG4, TMEM79, KRT84, HOXC13, LOC101116039, and MSX2 were identified in the red, green, and turquoise modules as being involved in the control of HF growth and development in sheep. This evidence concerns the gene ZDHHC21 and hydrops fetalis.