IL6 and infection: Subsequently, age, gender, BMI, rural population, complicated with underlying disease, infection site, invasive mechanical ventilation, CRRT, PCIS, PRISM, pSOFA scores on d1, and auxiliary examination [Lactate, PCT, CRP, IL-6, D-dimer, lymphopenia (<1.5 × 109/L), thrombocytopenia (<100 × 109/L), etc.] on d1 were included in the univariate and multivariate logistic regression analyses.