This side effect posesa serious drawback in the therapeutic use of cannabis for pain alleviation.Peptides designed from the transmembrane helices of CB1R, which are predicted to bind 5HT2AR and alter the stabilityof the CB1R-5HT2AR heteromer, have been shownto avert CB1R agonist-induced cognitive impairment whilepreserving analgesia. The gene discussed is CNR1; the disease is Cognitive impairment.