ACE and cardiovascular disorder: Relative to cardiovascular diseases, and according to the previous study, the centenarians used less antithrombotic agents, beta-blockers, and angiotensin-converting enzyme (ACE)-inhibitors than octogenarians and nonagenarians [153], being this finding consistent with the common notion that cardiovascular drug therapy is prescribed to a lesser extent in centenarians compared with younger groups of age [147, 154].