Taken together, the results shown so far indicate that (i) EGFR and HER2 were mainly plasma membrane located in PCa cells while ErbB3 may localize on the membrane, the cytoplasm or the nucleus; (ii) amiloride promoted ErbB3 translocation from the nucleus to the cytoplasm and the cytoplasm to the plasma membrane; (iii) as a result, amiloride enhanced HER2/ErbB3 dimerization, (iv) HER2 was activated by dimerization with ErbB3 and (v) activated HER2 enhanced downstream signaling and cell proliferation. The gene discussed is EGFR; the disease is posterior cortical atrophy.