DYRK1A and Dravet syndrome: Normalization of Dyrk1a dosage by genetic deletion of a single copy of the Dyrk1A gene from DS mice can partially rescue their cerebellar pathologies, displaying an increased density of GCs and PCs, and normalized dendritic arborization of PCs, further supporting the idea that Dyrk1A contributes to neuropathologies of cerebellar neurons in DS individuals [134].