Neurodegenerative diseases are often accompanied by intracellular and/or extracellular deposits, such as Aβ42-plaques that accumulate in Alzheimer’s disese (AD) affected brains, Lewy-bodies associated with Parkinson’s disease (PD), and cytoplasmic aggregates involving TDP-43 in Amyotrophic Lateral Sclerosis (ALS) [42]. Here, TARDBP is linked to amyotrophic lateral sclerosis.