PPARA and obesity due to melanocortin 4 receptor deficiency: Obesity and dietary fat intake are known to increase this rate‐limiting enzyme (Choi & Lee, 2023) and a protein phosphatase that inhibits peroxisome proliferator‐activated receptor (PPARα)‐mediated transcription of fatty acid oxidation‐related genes and fatty acid oxidation in mitochondria (Zhang et al., 2023).