TPO and hypothyroidism: TPO, as a crucial enzyme of synthesis of thyroid, mutation of which caused the clinical hypothyroidism or dishormonogenesis in human (Balmiki et al., 2014; Cangul et al., 2013; Pfarr et al., 2006; Tenenbaum‐Rakover et al., 2007; Turkkahraman et al., 2009).