Accordingly, several essential proteins involved in tumor progression were also discovered to be non-histone substrates of SETD7, including the tumor suppressor p53 (10, 11), nuclear factor kB (NF-kB) p65 (12), hypoxia-induced factor-1a (HIF-1a) (13), β-catenin (14), and the proto-oncogene KRAS (15). This evidence concerns the gene SETD7 and neoplasm.