The addition of measurement-based variables and variables that require prior medical examination (i.e., insulin use, number of treatments/medications taken, prevalent cardiovascular disease [other than CAD, and stroke diagnosed by a doctor]) and the further addition of biomarkers/other measurements (i.e., high-density lipoprotein [HDL] cholesterol, total cholesterol, and glycated haemoglobin) did not significantly improve QUES-CAD's performance in all instances, except for the White population (Supplementary Fig. S3, Supplementary Tables S10 and S11). This evidence concerns the gene INS and cardiovascular disorder.