Analysis using HemaCisDB revealed that SEs associated with B-cell-specific TF genes PAX5 and BCL2 are exclusively present in CLL compared to AML, as evidenced by enriched H3K27ac ChIP-seq and ATAC-seq signals in CLL cell line MEC1 and depleted signals in AML cell line MOLM-13 (Figure 5A). This evidence concerns the gene TF and acute myeloid leukemia.