This analysis revealed a significant enrichment of the IRF5 motif within open chromatin regions in MM cells (Figure 5E), consistent with previous findings that identified IRF5 regulon as a cancer-specific regulon with higher activity in MM cells vs. normal B cells using single-cell/single-nucleus RNA sequencing (RNA-seq) and single-nucleus ATAC-seq [46]. This evidence concerns the gene IRF5 and cancer.