Moreover, a recent study in diffuse large B cell lymphoma (DLBCL) showed that active super-enhancers (SEs) harboring hypermutation are linked to the upregulation of oncogenes related to B cell developmental and malignant transformation, including BCL6, BCL2, and CXCR4 [15]. The gene discussed is CXCR4; the disease is diffuse large B-cell lymphoma.