Acute kidney injury is characterized by a high inflammatory state, reduced cytokine clearance, and elevated levels of systemic cytokines, such as interleukin (IL)-17A, IL-6, IL-8, IL-1β, IL-12, and tumor necrosis factor (TNF)-α, which aggravate lung injury and increase the risk of lung infection [29, 30]. The gene discussed is CXCL8; the disease is acute kidney injury.