Subsequently, multivariate logistic regression analysis showed that liver failure (aOR = 5.23, 95% CI: 1.49–18.45, p = 0.01), hospital-acquired infection (aOR = 3.72, 95% CI: 1.02–13.52, p = 0.04), mechanical ventilator use (aOR = 7.42, 95% CI: 1.61–34.14, p = 0.01), and IL-6 ≥ 37 pg/mL (aOR = 20.25, 95% CI: 2.36–173.77, p = 0.01) were independent predictors of 28-day mortality in hospitalized patients with cirrhosis (Table 4). This evidence concerns the gene IL6 and Cirrhosis.