Hospitalized patients with cirrhosis who died within 28 days had significantly higher baseline levels of serum endocan (28.2 [IQR: 15.1–57.2] vs 12.2 [IQR: 7.0–34.3] ng/mL, p = 0.02), PCT (1466.4 [IQR: 561.8–4454.9] vs 302.2 [IQR: 167.2–945.1] pg/mL, p < 0.001), and IL-6 (84.2 [IQR: 51.3–397.3] vs 26.8 [IQR: 11.4–60.5] pg/mL, p < 0.001) than those who survived. This evidence concerns the gene CALCA and Cirrhosis.