PRNP and Alzheimer disease: In this study, we used a multidisciplinarystrategy to evaluatethe desirable features of a peptide, TP, with therapeutic potentialfor AD, including its bioavailability in a BBB model, metal-bindingpreference, and its impact on Cu2+ to proteins involvedin metal homeostasis and neuroprotection, such as PrP and its Cu2+-dependent colocalization with NMDARs.