Reduced tRNA m7G modification on tRNAs by knocking down of METTL1 severely impaired the translation of the tumour-related genes and pathways, including cell-cycle regulator Cyclin D3 (CCND3) [148], epidermal growth factor receptor (EGFR) [341], phosphatidylinositol 3-kinase (PI3K) and protein kinase B (AKT) [343]. The gene discussed is CCND3; the disease is neoplasm.