The lung injury score, W/D ratio, and levels of IL‐1β, IL‐6, and TNF‐α in the BALF (Figure 1H–L) revealed that treatment with GW4869 significantly reduced the extent of lung injury in TBI mice and TBI‐Exo‐induced ALI in mice, indicating that brain‐derived exosomes mediated TBI‐induced ALI. This evidence concerns the gene IL1B and acute respiratory distress syndrome.