Glabridin increases intracellular and mitochondrial ROS production, downregulates Akt and ERK1/2 phosphorylation to inhibit tumor cell proliferation, and upregulates p38 and JNK phosphorylation, increasing Bax, activating caspase-3 and PARP cleavage, and decreasing Bcl-2 to enhance apoptosis. Here, MAPK3 is linked to neoplasm.