Recently, it was reported that dihydroorotate dehydrogenase and aldo-keto reductase, in addition to GPX4, FSP1, and GCH1, are involved in the regulation of ferroptosis; therefore, it is desirable to examine the expression of these factors and analyze their molecular mechanisms in esophageal cancer cells (49, 50). Here, GCH1 is linked to esophageal cancer.