AIFM2 and esophageal cancer: Although no significant correlation was observed between 4-HNE expression and the prognosis in esophageal cancer tissues, 4-HNE metabolism by various enzymes, in addition to the extent of 4-HNE accumulation as lipid peroxidation is regulated by GPX4 and FSP1, may be observed and should be evaluated together with other lipid peroxidation markers.