The second most cited paper, authored by Sun X.F. from China and published in “Hepatology,” is titled “Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells.” This study reveals that the activation of the p62-Keap1-NRF2 pathway plays a crucial role in protecting against ferroptosis in HCC, leading scholars to explore key pathways involved in ferroptosis and shifting the research focus significantly. Here, KEAP1 is linked to hepatocellular carcinoma.