Multiple chromosomal rearrangements involving ETV6 (such as ETV6::RUNX1, ETV6::ABL1, ETV6::NTRK3, and ETV6::ACSL6) have been demonstrated to play a crucial role in the development of several hematologic diseases such as AML, as well as in their diagnosis and prognosis (11). The gene discussed is ACSL6; the disease is acute myeloid leukemia.