NFKB1 and neoplasm: At the same time, cytokines which are involved in the prevention of overshooting immune reactions were also elevated by Juzentaihoto, such as Interleukin 1 response element (IL-1ra) which abrogates NF-κB activation, and the γ-interferon response element CXCL10/IP10 which is involved in anti-tumor activity (Figures 5H, I).