INS and diabetes mellitus: HbA1c: Hemoglobin A1c; FDC: Fixed-Dose Combination; DAPA: Dapagliflozin; SITA: Sitagliptin; MET ER: Metformin Extended Release; MET SR: Metformin Sustained Release; T2D: Type 2 Diabetes; BMI: Body Mass Index; DAPA+SAXA: Dapagliflozin + Saxagliptin; GLIM: Glimepiride; MRI: Magnetic Resonance Imaging; TCT: Triple Combination Therapy (Metformin, Dapagliflozin, Saxagliptin); SAT: Sequential Add-on Therapy (Metformin, Glimepiride, Sitagliptin); INS: Insulin; T2DM: Type 2 Diabetes Mellitus; HDL: High-Density Lipoprotein